Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds.
Identifieur interne : 000146 ( Main/Exploration ); précédent : 000145; suivant : 000147Widespread contamination of coastal sediments in the Transmanche Channel with anti-androgenic compounds.
Auteurs : Diana Alvarez-Mu Oz [Royaume-Uni] ; Paolo Indiveri [Royaume-Uni] ; Pawel Rostkowski [Royaume-Uni] ; Julia Horwood [Royaume-Uni] ; Emily Greer [Royaume-Uni] ; Christophe Minier [France] ; Nick Pope [Royaume-Uni] ; William J. Langston [Royaume-Uni] ; Elizabeth M. Hill [Royaume-Uni]Source :
- Marine pollution bulletin [ 1879-3363 ] ; 2015.
Descripteurs français
- Wicri :
- geographic : France.
English descriptors
- KwdEn :
- Androgen Antagonists (analysis), Androgen Antagonists (metabolism), Androgen Antagonists (toxicity), Animals, Aquatic Organisms, Bivalvia (physiology), Environmental Monitoring, Estuaries, Female, France, Geologic Sediments (chemistry), Great Britain, Male, Polycyclic Hydrocarbons, Aromatic (analysis), Water Pollutants, Chemical (analysis), Water Pollutants, Chemical (metabolism), Water Pollutants, Chemical (toxicity).
- MESH :
- chemical , analysis : Androgen Antagonists, Polycyclic Hydrocarbons, Aromatic, Water Pollutants, Chemical.
- chemical , metabolism : Androgen Antagonists, Water Pollutants, Chemical.
- chemical , toxicity : Androgen Antagonists, Water Pollutants, Chemical.
- geographic : France, Great Britain.
- chemistry : Geologic Sediments.
- physiology : Bivalvia.
- Animals, Aquatic Organisms, Environmental Monitoring, Estuaries, Female, Male.
Abstract
This study analysed the levels of androgen receptor antagonist activity in extracts of coastal sediments sampled from estuaries in southern UK and northern France. Anti-androgenic (AA) activity varied between <0.2 and 224.3±38.4μg flutamide equivalents/g dry weight of sediment and was significantly correlated with the total organic carbon and silt content of samples. AA activity was detected in tissues extracts of clams, Scrobicularia plana, sampled from a contaminated estuary, some of which was due to uptake of a series of 4 or 5 ring polycyclic aromatic hydrocarbons (PAHs). Initial studies also indicated that fractionated extracts of male, but not female, clams also contained androgen receptor agonist activity due to the presence of dihydrotestosterone in tissues. This study reveals widespread contamination of coastal sediments of the Transmanche region with anti-androgenic compounds and these contaminants should be investigated for their potential to disrupt sexual differentiation in aquatic organisms.
DOI: 10.1016/j.marpolbul.2014.11.014
PubMed: 25496695
Affiliations:
- France, Royaume-Uni
- Angleterre, Haute-Normandie, Région Normandie, Sussex de l'Est
- Brighton, Falmer, Le Havre
- Université du Havre, Université du Sussex
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Le document en format XML
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Electronic address: E.M.Hill@sussex.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Life Sciences, University of Sussex, Brighton BN1 9QG</wicri:regionArea><orgName type="university">Université du Sussex</orgName><placeName><settlement type="city">Brighton</settlement><settlement type="town">Falmer</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Sussex de l'Est</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25496695</idno><idno type="pmid">25496695</idno><idno type="doi">10.1016/j.marpolbul.2014.11.014</idno><idno type="wicri:Area/PubMed/Corpus">000082</idno><idno type="wicri:Area/PubMed/Curation">000082</idno><idno type="wicri:Area/PubMed/Checkpoint">000082</idno><idno type="wicri:Area/Ncbi/Merge">000447</idno><idno type="wicri:Area/Ncbi/Curation">000447</idno><idno 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type="nation">Angleterre</region><region nuts="2" type="region">Sussex de l'Est</region></placeName></affiliation></author><author><name sortKey="Indiveri, Paolo" sort="Indiveri, Paolo" uniqKey="Indiveri P" first="Paolo" last="Indiveri">Paolo Indiveri</name><affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Life Sciences, University of Sussex, Brighton BN1 9QG</wicri:regionArea><orgName type="university">Université du Sussex</orgName><placeName><settlement type="city">Brighton</settlement><settlement type="town">Falmer</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Sussex de l'Est</region></placeName></affiliation></author><author><name sortKey="Rostkowski, Pawel" sort="Rostkowski, Pawel" uniqKey="Rostkowski P" first="Pawel" last="Rostkowski">Pawel Rostkowski</name><affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Life Sciences, University of Sussex, Brighton BN1 9QG</wicri:regionArea><orgName type="university">Université du Sussex</orgName><placeName><settlement type="city">Brighton</settlement><settlement type="town">Falmer</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Sussex de l'Est</region></placeName></affiliation></author><author><name sortKey="Horwood, Julia" sort="Horwood, Julia" uniqKey="Horwood J" first="Julia" last="Horwood">Julia Horwood</name><affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Life Sciences, University of Sussex, Brighton BN1 9QG</wicri:regionArea><orgName type="university">Université du Sussex</orgName><placeName><settlement type="city">Brighton</settlement><settlement type="town">Falmer</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Sussex de l'Est</region></placeName></affiliation></author><author><name sortKey="Greer, Emily" sort="Greer, Emily" uniqKey="Greer E" first="Emily" last="Greer">Emily Greer</name><affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Life Sciences, University of Sussex, Brighton BN1 9QG</wicri:regionArea><orgName type="university">Université du Sussex</orgName><placeName><settlement type="city">Brighton</settlement><settlement type="town">Falmer</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Sussex de l'Est</region></placeName></affiliation></author><author><name sortKey="Minier, Christophe" sort="Minier, Christophe" uniqKey="Minier C" first="Christophe" last="Minier">Christophe Minier</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Ecotoxicology, UPRES EA-3222, UFR de Sciences et Techniques, Université du Havre, 25 rue Philippe Lebon, BP 540, 76058 Le Havre Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Ecotoxicology, UPRES EA-3222, UFR de Sciences et Techniques, Université du Havre, 25 rue Philippe Lebon, BP 540, 76058 Le Havre Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName><orgName type="university">Université du Havre</orgName></affiliation></author><author><name sortKey="Pope, Nick" sort="Pope, Nick" uniqKey="Pope N" first="Nick" last="Pope">Nick Pope</name><affiliation wicri:level="1"><nlm:affiliation>Marine Biological Association, The Laboratory, Citadel Hill, Plymouth PL1 2PB, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Marine Biological Association, The Laboratory, Citadel Hill, Plymouth PL1 2PB</wicri:regionArea><wicri:noRegion>Plymouth PL1 2PB</wicri:noRegion></affiliation></author><author><name sortKey="Langston, William J" sort="Langston, William J" uniqKey="Langston W" first="William J" last="Langston">William J. Langston</name><affiliation wicri:level="1"><nlm:affiliation>Marine Biological Association, The Laboratory, Citadel Hill, Plymouth PL1 2PB, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Marine Biological Association, The Laboratory, Citadel Hill, Plymouth PL1 2PB</wicri:regionArea><wicri:noRegion>Plymouth PL1 2PB</wicri:noRegion></affiliation></author><author><name sortKey="Hill, Elizabeth M" sort="Hill, Elizabeth M" uniqKey="Hill E" first="Elizabeth M" last="Hill">Elizabeth M. Hill</name><affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom. Electronic address: E.M.Hill@sussex.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Life Sciences, University of Sussex, Brighton BN1 9QG</wicri:regionArea><orgName type="university">Université du Sussex</orgName><placeName><settlement type="city">Brighton</settlement><settlement type="town">Falmer</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Sussex de l'Est</region></placeName></affiliation></author></analytic><series><title level="j">Marine pollution bulletin</title><idno type="eISSN">1879-3363</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Androgen Antagonists (analysis)</term><term>Androgen Antagonists (metabolism)</term><term>Androgen Antagonists (toxicity)</term><term>Animals</term><term>Aquatic Organisms</term><term>Bivalvia (physiology)</term><term>Environmental Monitoring</term><term>Estuaries</term><term>Female</term><term>France</term><term>Geologic Sediments (chemistry)</term><term>Great Britain</term><term>Male</term><term>Polycyclic Hydrocarbons, Aromatic (analysis)</term><term>Water Pollutants, Chemical (analysis)</term><term>Water Pollutants, Chemical (metabolism)</term><term>Water Pollutants, Chemical (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Androgen Antagonists</term><term>Polycyclic Hydrocarbons, Aromatic</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Androgen Antagonists</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Androgen Antagonists</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term><term>Great Britain</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Geologic Sediments</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bivalvia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Aquatic Organisms</term><term>Environmental Monitoring</term><term>Estuaries</term><term>Female</term><term>Male</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study analysed the levels of androgen receptor antagonist activity in extracts of coastal sediments sampled from estuaries in southern UK and northern France. Anti-androgenic (AA) activity varied between <0.2 and 224.3±38.4μg flutamide equivalents/g dry weight of sediment and was significantly correlated with the total organic carbon and silt content of samples. AA activity was detected in tissues extracts of clams, Scrobicularia plana, sampled from a contaminated estuary, some of which was due to uptake of a series of 4 or 5 ring polycyclic aromatic hydrocarbons (PAHs). Initial studies also indicated that fractionated extracts of male, but not female, clams also contained androgen receptor agonist activity due to the presence of dihydrotestosterone in tissues. This study reveals widespread contamination of coastal sediments of the Transmanche region with anti-androgenic compounds and these contaminants should be investigated for their potential to disrupt sexual differentiation in aquatic organisms.</div></front></TEI><affiliations><list><country><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Haute-Normandie</li><li>Région Normandie</li><li>Sussex de l'Est</li></region><settlement><li>Brighton</li><li>Falmer</li><li>Le Havre</li></settlement><orgName><li>Université du Havre</li><li>Université du Sussex</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Alvarez Mu Oz, Diana" sort="Alvarez Mu Oz, Diana" uniqKey="Alvarez Mu Oz D" first="Diana" last="Alvarez-Mu Oz">Diana Alvarez-Mu Oz</name></region><name sortKey="Greer, Emily" sort="Greer, Emily" uniqKey="Greer E" first="Emily" last="Greer">Emily Greer</name><name sortKey="Hill, Elizabeth M" sort="Hill, Elizabeth M" uniqKey="Hill E" first="Elizabeth M" last="Hill">Elizabeth M. Hill</name><name sortKey="Horwood, Julia" sort="Horwood, Julia" uniqKey="Horwood J" first="Julia" last="Horwood">Julia Horwood</name><name sortKey="Indiveri, Paolo" sort="Indiveri, Paolo" uniqKey="Indiveri P" first="Paolo" last="Indiveri">Paolo Indiveri</name><name sortKey="Langston, William J" sort="Langston, William J" uniqKey="Langston W" first="William J" last="Langston">William J. Langston</name><name sortKey="Pope, Nick" sort="Pope, Nick" uniqKey="Pope N" first="Nick" last="Pope">Nick Pope</name><name sortKey="Rostkowski, Pawel" sort="Rostkowski, Pawel" uniqKey="Rostkowski P" first="Pawel" last="Rostkowski">Pawel Rostkowski</name></country><country name="France"><region name="Région Normandie"><name sortKey="Minier, Christophe" sort="Minier, Christophe" uniqKey="Minier C" first="Christophe" last="Minier">Christophe Minier</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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